|
|
| Gene : |
NLRP3 |
| Gene ID : |
114548 |
| Uniprot ID : |
Q96P20 |
| Alternative Name : |
NLRP3, C1orf7, CIAS1, NALP3, PYPAF1 |
| Format : |
Purified |
| Amount : |
100 µg |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A partial recombinant NALP3 protein (amino acids 1-200) was used as the immunogen for this antibody. |
NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein-protein interaction, an intermediate nucleotide binding self-oligomerization NACHT domain and a C-terminal domain containing leucine-rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappa? signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.
Western blot analysis: 2-4 µg/ml
