|
|
| Gene : |
SPIB |
| Gene ID : |
6689 |
| Uniprot ID : |
Q01892 |
| Alternative Name : |
SPIB |
| Format : |
Purified |
| Amount : |
100 µg |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
Full length recombinant SpiB protein was used as the immunogen for this antibody. |
Spi-B belongs to the ETS family transcription factor containing a conserved ETS domain which specifically binds to a purine-rich DNA sequence called the PU-box (5'-GAGGAA-3'). Spi-B has two known isoforms (28 and 18 kDa) and is localized in nucleus and cytoplasm. Spi-B contains two transactivation domains (TAD) at the N-terminal end which may be required for transcriptional activation of the target genes. Spi-B is involved in development of plasmacytoid dendritic cells (natural interferon producing cells) and B-cell development. Spi-B acts as a lymphoid specific enhancer. Spi-B is highly expressed in plasmacytoid dendritic cells (pDCs), B-cells and stem cell populations of the liver.
Western blot analysis: 2-4 µg/ml
