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|
| Gene : |
TRAF3 |
| Gene ID : |
7187 |
| Uniprot ID : |
Q13114 |
| Alternative Name : |
TRAF3, CAP1, CRAF1 |
| Format : |
Sera |
| Amount : |
50 µl |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A recombinant protein fragment of the cytoplasmic end of human TRAF-3 (amino acids 341-568) was used as immunogen for this antibody |
This antibody recognizes TRAF3. Human TRAF3 is a member of the, TRAF (TNF Receptor Associated Factor) protein family, having an approximate molecular weight of 568 amino acid.TRAF3 is a CD40 binding protein that contains a RING finger DNA binding motif and Cys/His rich region and coiled COIL domain. Like TRAF1 (TNF Receptor Associated Factor-1) and TRAF2 (TNF Receptor Associated Factor-2), it contains a C-terminal TRAF domain and has an apparent molecular mass of 64 kDa.TRAF3 is involved in mediating the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the, LtBetaR (Lymphotoxin-Beta Receptor) signaling complex, which induces NF-KappaB activation and cell death initiated by LT-Beta (Lymphotoxin-Beta) ligation.
WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
