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| Alternative Name : |
Signal-Regulatory Protein Alpha, SHPS1, CD172
Antigen-Like Family Member A, Inhibitory Receptor SHPS-1, Macrophage Fusion
Receptor, PTPNS1, SIRP, P84, BIT, MFR,
Brain-Immunoglobulin-Like Molecule With Tyrosine-Based
Activation Motifs, Brain Ig-Like |
| Amount : |
20 µg |
Source : Escherichia Coli.
SIRPA Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 370 amino acids (27-373 a.a) and
having a molecular mass of 40.4kDa.
SIRPA is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Signal-Regulatory Protein Alpha, SIRPA belongs to the
signal-regulatory-protein (SIRP) family, as well as the immunoglobulin super family. The members
of the SIRP family are receptor-type
transmembrane glycoproteins which are involved in the negative regulation of receptor tyrosine
kinase-coupled signaling processes. SIRPA can be phosphorylated
by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown
to recruit SH2 domain
containing tyrosine phosphatases (PTP), and perform as substrates of PTPs. SIRPA take part in signal transduction mediated by a variety
of growth factor receptors. CD47 has been shown to be a ligand for SIRPA.
