|
|
| Gene : |
SFN |
| Gene ID : |
2810 |
| Uniprot ID : |
P31947 |
| Alternative Name : |
SFN, HME1 |
| Format : |
Purified |
| Amount : |
100 µg |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
Full length recombinant 14-3-3 sigma protein was used as the immunogen for this antibody. |
14-3-3 sigma is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known human 14-3-3 isotypes and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker 1 and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3? is the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to ?-irradiation and other DNA-damaging agents. 14-3-3? is a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5? CpG islands in epithelial tumor cells. Two isoforms of the human proteins are produced by alternative splicing.
Western blot analysis: 1-3 µg/ml, Immunohistochemical analysis: 10 µg/ml
