|
|
| Gene : |
PDX1 |
| Gene ID : |
3651 |
| Uniprot ID : |
P52945 |
| Alternative Name : |
IPF1, IUF1, IDX-1, MODY4, PDX1, STF-1, Insulin promoter factor 1, Pancreas Duodenum Homeobox-1. |
| Format : |
Purified |
| Amount : |
50 µl |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
Recombinant PDX1 E.Coli derived. |
PDX1 activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. IPF1 is particularly involved in glucose-dependent regulation of insulin gene transcription. Pancreas Duodenum Homeobox-1 binds preferentially the DNA motif 5'-[ct]taat[tg]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, it is required for maintaining the hormone-producing phenotype of the beta-cell.
Western Blot: 1:1,000, Immunohistochemistry: 1:500, Optimal working dilutions must be determined by end user. Routinely evaluated by western blot on lysates of rat pancreatic cell line INS-1.
