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Alternative Name : |
ASF, MGC5228, SF2, SF2p33, SRp30a, Serine/arginine-rich splicing factor 1, SRSF1, splicing factor 1, ASF-1, Splicing factor, arginine/serine-rich 1, pre-mRNA-splicing factor SF2, P33 subunit, OK/SW-cl.3. |
Amount : |
20 µg |
Source : Escherichia Coli.
SRSF1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 268 amino acids (1-248) and having a molecular mass of 29.9 kDa.SRSF1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Serine/arginine-rich splicing factor 1 (SFRS1) belongs to the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. SFRS1 binds to pre-mRNA transcripts and components of the spliceosome, and can either initiate or inhibit splicing depending on the position of the pre-mRNA binding site. The ability of SFRS1 to activate splicing is controlled by phosphorylation and interactions with other splicing factor associated proteins.