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| Gene ID : |
NP_002692.2 |
| Uniprot ID : |
Q01860 |
| Amount : |
100 µg |
| Immunogen Information : |
OCT4 (1a.a - 360 a.a.) recombinant protein with an N-terminal His-PTD-NLS tag. |
Molecular weight: 48 kDa
Expression system: E. coli
Recombinant, 6xHis tag
OCT4 (Octamer binding transcription factor 4) is a key regulator of self-renewal in embryonic stem cells. It is a homeodomain transcription factor belonging to POU family. OCT4 is frequently used as a marker for undifferentiated cells. This factor is one of the four original Yamanaka Factors and has been shown to be essential for pluripotency of embryonic stem cells. Along with SOX2, KLF4 and c-Myc, it can reprogram somatic or differentiated cells into induced pluripotent stem cells (iPSCs).
The recombinant protein is tagged with nuclear localization signal (NLS), a protein translocation domain (PTD, a poly arginine cell-penetrating peptide) and 6xHis at N-terminal region of the protein. The PTD will allow the entry of transcription factors through the plasma membrane and the NLS will allow entry of the proteins in to the nucleus to exert their biological actions.
Cell culture, WB, ELISA, EMSA
