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| Gene ID : |
L07335.1 |
| Uniprot ID : |
P48431 |
| Amount : |
100 µg |
| Immunogen Information : |
SOX2 (AAH13923, 1 a.a. - 318 a.a.) recombinant protein with an N terminal His-PTD-NLS tag. |
Domains : HMG box DNA-binding domain
Molecular weight : 44 kDa
Recombinant, 6xHis tag
Expression system: E. coli
SOX2 (SRY-related HMG-Box Gene 2) is a helix-loop helix transcription factor, which controls the expression of a number of genes involved in embryonic development. The SOX2 family of transcription factors have been shown to play key roles in mammalian development. The SOX2 factor is the one of the four original Yamanaka Factors and has been shown to be essential for pluripotency of embryonic stem cells. Along with Oct-4, KIf-4 and cmyc, it can reprogram somatic or differentiated cells into induced pluripotent stem cells (iPSCs). The recombinant protein is tagged with nuclear localization signal (NLS), a protein translocation domain (PTD, a poly arginine cell-penetrating peptide) and 6xHis at N-terminal region of the protein. The PTD will allow the entry of transcription factors through the plasma membrane and the NLS will allow entry of the proteins in to the nucleus to exert their biological actions.
